The birth of Nardi's son Paul in 1926 and the responsibilities of motherhood required Nardi to curtail her writing in order to earn a living through odd jobs (such as clerking at a department store, waitressing, and proofreading). In 1942 Nardi met William Carlos Williams with whom she began a correspondence. Williams used Nardi's letters, which discuss the difficulties of being a female poet in contemporary literary circles, in his epic poem ''Paterson''. Williams also encouraged Nardi to publish her poetry, an endeavor that came to fruition with Nardi's first book ''Poems'' published by Swallow Press in 1956. In the 1940s Nardi married painter and writer John Charles Lang and the couple resided in a community of artists called Maverick Colony.
Nardi worked extensively with John Edmunds between 1972 and 1983 with the intention of publishing a collection of her poetry; however this project did not result in a publication before Nardi's death in 1990.